Touta Konoe is a country boy raised by his teacher Yukihime, dreaming of one day climbing the great tower at the center of the world. When bounty hunters attack and he is fatally wounded, Yukihime's blood turns him immortal and reveals her as the centuries-old vampire Evangeline A.K. McDowell. Leaving his hometown behind, Touta joins UQ Holder, the secret society of immortals she once led. Set decades after Negima!, the manga follows Touta and his fellow immortals into the wider world.