Exorcist ninja Matsuri Kazamaki has spent years shielding his childhood friend Suzu Kanade, an ayakashi medium whose power draws spirits to her. When Shirogane, the self-proclaimed King of Ayakashi, targets Suzu directly, Matsuri manages to seal most of the creature's power, but not before Shirogane curses him, transforming his body from male to female. Now stuck in an unfamiliar form, Matsuri continues to protect Suzu while searching for a way to reverse the curse.