Lord Kagemitsu Daigo strikes a pact with 48 demons, trading away his newborn son's body parts for the power to conquer the land, and has the deformed infant set adrift on a river. That child grows into Hyakkimaru, a wandering swordsman fitted with prosthetics who hunts down each of the 48 demons to reclaim what was taken from him. This 1969 series, based on Osamu Tezuka's manga, follows his journey alongside a scrappy young thief named Dororo, who latches onto Hyakkimaru for protection.