Yuichiro Hyakuya has reunited with his childhood friend Mikaela at the Shinjuku battle, only to find Mika has become a vampire. With the main vampire army preparing to advance on Tokyo within a month, Lieutenant Colonel Guren Ichinose receives orders to strike first at the nobles stationed in Nagoya. Yuichiro joins Shinoa's squad for the extermination mission, still searching for a way to save Mika while mastering the Cursed Gear that gives his unit an edge against the vampire nobility. This second season continues directly from the first.