Ergo Proxy follows Re-l Mayer, a city inspector in the domed metropolis of Romdo who investigates murders carried out by rogue AutoReivs. Her investigation draws in Vincent Law, a quiet AutoReiv host, and leads to encounters with the enigmatic Proxy known as Ergo Proxy. The series blends psychological mystery with philosophical musings on identity, memory, and what it means to be human in a world where reality itself is questioned.

Ergo Proxy follows Re-l Mayer, a city inspector in the domed metropolis of Romdo who investigates murders carried out by rogue AutoReivs. Her investigation draws in Vincent Law, a quiet AutoReiv host, and leads to encounters with the enigmatic Proxy known as Ergo Proxy. The series blends psychological mystery with philosophical musings on identity, memory, and what it means to be human in a world where reality itself is questioned.