Vash the Stampede crosses the desert world of No Man's Land with a sixty-billion double-dollar bounty on his head and a vow never to take a life, disarming the hunters and killers who come for him instead of shooting to kill. What he is really looking for is his brother Knives. Travelling with him at times is Nicholas D. Wolfwood, a priest who carries a cross-shaped arsenal on his back. This sequel picks up directly from the original Trigun manga.